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(Acylaryloxy)acetic acid diuretics. 5. [(2-Alkyl- and 2,2-disubstituted-1,3-dioxo-5-indanyl)oxy]acetic acids.

作者信息

Woltersdorf O W, deSolms S J, Stokker G E, Cragoe E J

出版信息

J Med Chem. 1984 Jul;27(7):840-5. doi: 10.1021/jm00373a005.

DOI:10.1021/jm00373a005
PMID:6737427
Abstract

Investigation of the chemistry of the potent uricosuric diuretic indacrinone (MK-196) prompted the synthesis of a series of 3-oxo derivatives, i.e., the indan-1,3-diones. In general, both pharmacological parameters (uricosuria and diuresis) were significantly less pronounced with the 1,3-diones than with the parent 1-oxo compounds.

摘要

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