Ishide N, Watanabe H, Takishima T
J Mol Cell Cardiol. 1984 May;16(5):421-6. doi: 10.1016/s0022-2828(84)80613-6.
Spontaneous sarcomere motions in isolated rat cardiac muscle were measured by recording the light intensity at a point of magnified muscle image. The spontaneous sarcomere motions were located near the cut end, and not evenly distributed along the muscle. Calcium depletion markedly decreased the amplitude of the light intensity fluctuations. In all cases, calcium readmission after 5 min calcium depletion (calcium paradox), which has been known to injure myocardium, increased the amplitude of the light intensity fluctuation than that under control conditions. Thus, cell injury enhances spontaneous sarcomere motions. While it remains unclear whether or not cell injury is a prerequisite for spontaneous sarcomere motions, under certain conditions the area of myocardial damage can be detected by the existence of spontaneous sarcomere motions.
通过记录放大的肌肉图像上某一点的光强度，测量了分离的大鼠心肌中自发的肌节运动。自发的肌节运动位于切断端附近，且沿肌肉分布不均匀。钙耗竭显著降低了光强度波动的幅度。在所有情况下，已知会损伤心肌的钙耗竭5分钟后再灌注钙（钙反常），会使光强度波动的幅度比对照条件下增加。因此，细胞损伤会增强自发的肌节运动。虽然尚不清楚细胞损伤是否是自发肌节运动的先决条件，但在某些情况下，可通过自发肌节运动的存在来检测心肌损伤区域。
