Kalra S P, Crowley W R
Neuroendocrinology. 1984 Jun;38(6):511-3. doi: 10.1159/000123941.
Observations that a pancreatic polypeptide-like substance is present in hypothalamus and may coexist with catecholamines prompted evaluation of its possible role in control of luteinizing hormone (LH) secretion. Intracerebroventricular administration of 0.5 or 2 micrograms of human pancreatic polypeptide to ovariectomized, hormonally untreated rats significantly decreased LH levels. However, when administered to ovariectomized rats pretreated with estradiol benzoate and progesterone, the neuropeptide significantly increased circulating LH in a dose-related manner. These results, which are similar to those reported for centrally administered norepinephrine, raise the possibility that pancreatic polypeptide, or a similar peptide, may participate in the physiologic regulation of LH release, either independently or perhaps as a neuromodulator or a cotransmitter with catecholamines.
有观察发现，下丘脑存在一种类似胰多肽的物质，且可能与儿茶酚胺共存，这促使人们评估其在促黄体生成素（LH）分泌控制中可能发挥的作用。对去卵巢且未接受激素处理的大鼠进行脑室内注射0.5微克或2微克人胰多肽后，LH水平显著降低。然而，当对用苯甲酸雌二醇和孕酮预处理过的去卵巢大鼠给药时，这种神经肽会以剂量相关的方式显著提高循环中的LH水平。这些结果与中枢给予去甲肾上腺素的报道结果相似，提示胰多肽或类似肽可能独立地，或者也许作为一种神经调节剂或与儿茶酚胺共同传递的递质，参与LH释放的生理调节。
