Fariello R G, Zeeman E, Golden G T, Reyes P T, Ramacci T
Neuropharmacology. 1984 May;23(5):585-7. doi: 10.1016/0028-3908(84)90033-9.
Intracerebral injection of L-acetylcarnitine in rats induced interictal and ictal epileptic phenomena with immediate onset, lasting up to 4 h. Pretreatment with systemic atropine prevents all epileptiform phenomena. Local injection of muscimol and THIP abolish ictal events, but not single spikes. L-carnitine induced only ictal discharges with a latency of 40-90 min. Acetylcarnitine epileptogenic properties are probably related to muscarinic agonism. The transition from interictal to ictal events may involve failure of GABAergic mechanisms.
向大鼠脑内注射L-乙酰肉碱会立即引发发作间期和发作期癫痫现象，持续长达4小时。全身使用阿托品预处理可预防所有癫痫样现象。局部注射蝇蕈醇和THIP可消除发作期事件，但不能消除单个棘波。L-肉碱仅诱导发作期放电，潜伏期为40-90分钟。乙酰肉碱的致癫痫特性可能与毒蕈碱激动作用有关。从发作间期到发作期事件的转变可能涉及γ-氨基丁酸能机制的失效。
