Seigneurin D, Audhuy B, Leger J, Hollard D
Nouv Rev Fr Hematol (1978). 1984;26(3):179-87.
Cytological and kinetic findings in 56 patients with refractory anemia with excess blasts (RAEB) were studied. The different statistical methods used produce similar results: our group of patients can be separated by cytological parameters in two populations (overt leukemic or hematologically stable evolution). Different functional lesions may be responsible for these two types; pluripotential stem cell dysfunction in the first case and abnormality of the granulocytic committed stem cell in the second. A score, based on a small number of simple and reliable parameters, is able to distinguish these two populations.
对56例伴有过多原始细胞的难治性贫血（RAEB）患者的细胞学和动力学结果进行了研究。所使用的不同统计方法产生了相似的结果：我们的患者群体可以通过细胞学参数分为两类（明显白血病或血液学稳定进展）。这两种类型可能由不同的功能损伤引起；第一种情况是多能干细胞功能障碍，第二种情况是粒系定向干细胞异常。基于少量简单可靠参数的评分能够区分这两类人群。
