霍奇金病与亚急性小脑变性。一例报告并文献复习。

Hodgkin's disease and subacute cerebellar degeneration. A case report and review of the literature.

作者信息

Cavo M, Zaccaria A, d'Alessandro R, Galieni P, Del Zotto E

出版信息

Nouv Rev Fr Hematol (1978). 1984;26(3):197-9.

Abstract

Case history of a 20-year old man with Hodgkin's disease, clinical stage I, lymphocytic predominance, complicated by a subacute cerebellar degeneration, which was diagnosed by computed tomography scan. Following local radiotherapy, cerebellar and brain stem symptoms and signs had a complete regression. Two months later, a recurrence of the neurological picture was recorded: polychemotherapy (MOPP) was then administered and after 5 courses the symptoms improved considerably. The association of subacute cerebellar degeneration with Hodgkin's disease is rare: only 10 cases have previously been described. Pathogenesis of cerebellar atrophy complicating tumors is undetermined.

摘要

一名20岁霍奇金病男性患者的病例史，临床分期为I期，淋巴细胞为主型，并发亚急性小脑变性，经计算机断层扫描确诊。局部放疗后，小脑和脑干症状及体征完全消退。两个月后，神经症状复发：随后给予多药联合化疗（MOPP），5个疗程后症状明显改善。亚急性小脑变性与霍奇金病的关联罕见：此前仅报道过10例。肿瘤并发小脑萎缩的发病机制尚不清楚。