Botez M I, Botez T, Maag U
Psychol Med. 1984 May;14(2):431-7. doi: 10.1017/s0033291700003688.
Forty-nine patients with low serum and cerebrospinal fluid folate levels completed the Ottawa-Wechsler Scale after 7-11 months of folate supplementation (10 mg daily). Twelve patients exhibited major neurological symptoms, while 37 patients displayed depression and minor neurological signs. After folate therapy, Verbal, Performance and Full Wechsler scores were significantly improved (P less than 0.001). The order of improvement in scores on the Wechsler subtests (from the statistically most significant to the least as measured by the t-statistics) was: Block Design, Digit Symbol, Similarities, Picture Completion, Picture Arrangement, Arithmetic, Object Assembly, Digit Span, Information, and Comprehension.
49名血清和脑脊液叶酸水平较低的患者在补充叶酸（每日10毫克）7至11个月后完成了渥太华-韦氏智力量表测试。12名患者出现主要神经症状，37名患者表现出抑郁和轻微神经体征。叶酸治疗后，韦氏语言、操作和总智商得分显著提高（P<0.001）。韦氏分测验得分改善的顺序（从t检验统计学意义最显著到最不显著）为：积木图案、数字符号、相似性、图片完成、图片排列、算术、图形拼凑、数字广度、知识和领悟。
