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[热疗对不同生物系统的放射增敏及损伤作用。热疗对小鼠造血干细胞的放射增敏及损伤作用]

[Radiosensitizing and damaging action of hyperthermia on different biological systems. Radiosensitizing and damaging action of hyperthermia on mouse hematopoietic stem cells].

作者信息

Konopliannikov A G, Konopliannikova O A, Trishkina A I, Shteĭn L V

出版信息

Radiobiologiia. 1984 May-Jun;24(3):325-9.

PMID:6739734
Abstract

Dose dependences of heat-induced inactivation of CFUs have been described for the temperature range of 41 to 44 degrees C. The energy of activation of the processes of thermal death was 100-120 kcal/M. CFUs were more resistant to heating than the cells of mouse leukaemia. Heating 1 h or immediately before irradiation had a radiosensitizing effect on CFUs. When bone marrow cells were heated 1 h after irradiation the radiosensitizing effect was absent: there was only a simple summation of the effects of the two damaging agents.

摘要

已描述了在41至44摄氏度温度范围内,集落形成单位(CFUs)热诱导失活的剂量依赖性。热死亡过程的活化能为100 - 120千卡/摩尔。CFUs比小鼠白血病细胞对加热更具抗性。加热1小时或在辐照前立即加热对CFUs有放射增敏作用。当骨髓细胞在辐照后1小时加热时,放射增敏作用不存在:仅两种损伤剂的作用简单相加。

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