布加勒斯特冠心病多因素预防试验——十年随访：1971 - 1982年
The Bucharest Multifactorial Prevention Trial of Coronary Heart Disease--ten year follow-up: 1971-1982.
作者信息
Steinbach M, Constantineanu M, Georgescu M, Harnagea P, Theodorini S, Galfi L, Damşa T, Schioiu L, Mitu S, Popescu A
出版信息
Med Interne. 1984 Apr-Jun;22(2):99-106.
The trial begun in 1971 and the paper brings the results after a ten-year follow-up. Both the intervention and control group contained 5000 men with a similar socioeconomic and professional structure; the intervention group was examined every six months in the first 5 years and annually in the second phase. The control group was examined "only after" 5 years and a second time at the final moment. The decreases of the cumulative ten-year incidences were: for hard events--26.7%; for myocardial infarction--20%; for fatal myocardial infarction--52%; for stroke--31%; for cardiovascular mortality--38%; for total mortality--14%. The trend of serum cholesterol and cigarettes/day was downward, but the blood pressure had a rather flat evolution in the intervention group. The control group disclosed also some downward trends.
该试验始于1971年，本文给出了十年随访后的结果。干预组和对照组均有5000名男性，他们具有相似的社会经济和职业结构；干预组在前5年每6个月检查一次，第二阶段每年检查一次。对照组仅在5年后检查一次，最后再检查一次。十年累计发病率的下降情况为：严重事件——26.7%；心肌梗死——20%；致命性心肌梗死——52%；中风——31%；心血管死亡率——38%；总死亡率——14%。干预组中血清胆固醇和每日吸烟量呈下降趋势，但血压变化较为平稳。对照组也呈现出一些下降趋势。
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