Leppik I E, Cloyd J C, Miller K
Ther Drug Monit. 1984;6(2):189-91. doi: 10.1097/00007691-198406000-00010.
Side effects and antiepileptic drug levels were measured during initiation of and chronic treatment with primidone (PRM). A significant change in the toxicity/serum level ratio was observed 6 h after the initial PRM dose. The amount of toxicity manifested by patients receiving PRM as their initial antiepileptic drug was not different from that of those patients previously treated with phenytoin (PHT) or carbamazepine (CBZ). These findings indicate rapid development of functional tolerance to side effects of PRM, which is not altered by previous exposure to PHT or CBZ. Phenobarbital pretreatment appears to produce cross-tolerance to the effects of PRM.
在使用扑米酮（PRM）开始治疗及长期治疗期间，对副作用和抗癫痫药物水平进行了测量。在首次给予PRM剂量6小时后，观察到毒性/血清水平比值有显著变化。以PRM作为初始抗癫痫药物的患者所表现出的毒性程度，与先前接受苯妥英（PHT）或卡马西平（CBZ）治疗的患者并无差异。这些发现表明，对PRM副作用的功能性耐受性迅速发展，且先前接触PHT或CBZ并不会改变这种耐受性。苯巴比妥预处理似乎会产生对PRM作用的交叉耐受性。
