Kosovskiĭ M I, Gagel'gans A I, Khusainova F A, Akhmedova N U, Guliamov T D
Tsitologiia. 1984 Apr;26(4):409-14.
The influence of calcium ionophores--tenoyltrifluoroacetate (TTFA) and divaleryldibenzo-18-crown-6(divaleryl) on the glucose consumption, D-xylose transport and glycogen content in rat diaphragm was studied. TTFA caused a clear dose-dependent inhibition of carbohydrate transport and glycogenolysis stimulation. Divaleryl, on the other hand, raised glucose consumption, D-xylose transport without influencing glycogen content. Exclusion of Ca++ from incubation medium increased the TTFA inhibiting effect on glucose consumption, decreased its glycogenolytic effect and removed divaleryl induced stimulation of glucose transport. Mechanisms of calcium ionophore action and a possible role of intracellular Ca2+ in carbohydrate transport are discussed.
研究了钙离子载体——三氟乙酰三癸酰（TTFA）和二戊酰二苯并-18-冠-6（二戊酰）对大鼠膈肌葡萄糖消耗、D-木糖转运和糖原含量的影响。TTFA引起了明显的剂量依赖性碳水化合物转运抑制和糖原分解刺激。另一方面，二戊酰提高了葡萄糖消耗和D-木糖转运，而不影响糖原含量。从孵育培养基中去除Ca++增加了TTFA对葡萄糖消耗的抑制作用，降低了其糖原分解作用，并消除了二戊酰诱导的葡萄糖转运刺激。讨论了钙离子载体的作用机制以及细胞内Ca2+在碳水化合物转运中的可能作用。
