Pashkov D, Mutafchieva R, Drumev D, Koĭchev K B, Avramova N
Vet Med Nauki. 1984;21(4):84-93.
In calves (cross-breds--Bulgarian Brown Cattle breed and Black Spot Cattle bred) weighing about 189 kg pharmacokinetics of sulphadoxine (SD) and trimethoprim (TMP) was studied. The two substances were administered in combination (5 + 1) as a dosage form Tridoxin (Pharmachim, Bulgaria; 24% injectable solution) (TD) at a dose 15 mg/kg m. The results show that after intramuscular administration TD is absorbed relatively rapidly. SD and TMP have systemic availability 94.1 +/- 18.1% and 52.5 +/- 6.2% and produce blood levels, after a single dose of TD, higher than potentiated minimum inhibitory concentrations for 24-48 h and 5(4-8) h, respectively. Upon intravenous administration the two-compartmental model is applicable for the distribution and elimination of SD and TMP (for TMP in part of the animals one-compartmental model is applicable). The two substances are distributed relatively widely in organs and tissues. The biological half-life of TD--t1/2 beta for SD is 14.36 +/- 1.40 h and for TMP--2.40 +/- 0.31 (for one-compartmental model--1.92 +/- 0.26) h, Vd--429.9 +/- 16.9 ml/kg and for TMP in part of the animals one-compartmental model is applicable). The two substances are distributed relatively widely in organs and tissues. The biological half-life of TD--t1/2 beta for SD is 14.36 +/- 1.40 h and for TMP--2.40 +/- 0.31 (for one-compartmental model--1.92 +/- 0.26) h, Vd--429.9 +/- 16.9 ml/kg and for TMP in part of the animals one-compartmental model is applicable). The two substances are distributed relatively widely in organs and tissues. The biological half-life of TD--t1/2 beta for SD is 14.36 +/- 1.40 h and for TMP--2.40 +/- 0.31 (for one-compartmental model--1.92 +/- 0.26) h, Vd--429.9 +/- 16.9 ml/kg and 655.8 +/- 77.6 (for one-compartmental model--671.7 +/- 40.0) ml/kg, ClB--0.35 +/- 0.02 ml/kg/min and 2.87 +/- 0.35 (for one-compartmental model--4.15 +/- 0.80) ml/kg/min, respectively. After intramuscular injection at the dose used a suitable withdrawal time for meat and internal organs is 5 days and for milk--2 days.
对体重约189千克的犊牛（杂交品种——保加利亚褐牛和黑斑牛）进行了磺胺多辛（SD）和甲氧苄啶（TMP）的药代动力学研究。两种物质以（5 + 1）组合形式作为制剂Tridoxin（保加利亚Pharmachim公司生产；24%注射溶液）（TD），以15毫克/千克体重的剂量给药。结果表明，肌内注射TD后吸收相对较快。SD和TMP的全身利用率分别为94.1±18.1%和52.5±6.2%，单剂量TD给药后，其血药浓度分别在24 - 48小时和5（4 - 8）小时内高于增效最小抑菌浓度。静脉给药后，二室模型适用于SD和TMP的分布与消除（部分动物的TMP适用一室模型）。这两种物质在器官和组织中的分布相对广泛。TD的生物半衰期——SD的t1/2β为14.36±1.40小时，TMP的为2.40±0.31小时（一室模型为1.92±0.26小时），Vd——SD为429.9±16.9毫升/千克，部分动物的TMP适用一室模型。这两种物质在器官和组织中的分布相对广泛。TD的生物半衰期——SD的t1/2β为14.36±1.40小时，TMP的为2.40±0.31小时（一室模型为1.92±0.26小时），Vd——SD为429.9±16.9毫升/千克，TMP为655.8±77.6（一室模型为671.7±40.0）毫升/千克，ClB——SD为0.35±0.02毫升/千克/分钟，TMP为2.87±0.35（一室模型为4.15±0.80）毫升/千克/分钟。按所用剂量肌内注射后，肉和内脏的适宜休药期为5天，牛奶为2天。
