Reinhardt R, Schauer J, Faust H
Z Erkr Atmungsorgane. 1984;162(2):128-33.
A new isotope method for the determination of the residual volume of the lungs by means of stable, non-radioactive nitrogen isotope 15N is described. Normal air is breathed in a closed system. One part of the air nitrogen is replaced by 15N labelled molecular nitrogen. 15N2 physiologically acts like normal nitrogen so that the so-called secondary effects by using He or H2 are eliminated. By combination of a spirograph and an emission spectrometric 15N analyser the residual volume can be determined and mixing curves can be obtained. The determination of the residual volume in 10 healthy persons gives a range of normal values from 19 to 31% of the total capacity. In three persons with emphysema values from 45 to 50% of the total capacity are found. The analysis of mixing curves leads to additional informations concerning the intrapulmonary gas mixing conditions in the lungs. The relative error of the residual volume determination is about 8%.
本文描述了一种通过稳定的非放射性氮同位素15N测定肺残气量的新同位素方法。在封闭系统中吸入正常空气。空气中的一部分氮气被15N标记的分子氮取代。15N2在生理上的作用与正常氮气相同，因此消除了使用氦气或氢气时的所谓二次效应。通过结合肺量计和发射光谱15N分析仪，可以测定残气量并获得混合曲线。对10名健康人的残气量测定得出正常值范围为总容量的19%至31%。在三名肺气肿患者中，发现残气量占总容量的45%至50%。对混合曲线的分析得出了有关肺内气体混合情况的更多信息。残气量测定的相对误差约为8%。
