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[使用骨骼肌孤立性负荷过重的生物学模型来确定合成代谢类固醇的作用]

[Use of a biological model of isolated overload of the skeletal muscle for determination of the effect of anabolic steroids].

作者信息

Ivanenko T I, Fedotov V P, Almaeva S N, Belen'kiĭ E E

出版信息

Probl Endokrinol (Mosk). 1978 May-Jun;24(3):108-13.

PMID:674122
Abstract

The authors tested a new biological model for the quantitative determination of the anabolic effect of steranobols of prolonged action. The principle of the method consists in creation of an isolated overload of the skeletal muscles of the shin (m. soleus and. m. plantaris) following section of the tendons of their synergist--m. gastrocnemius in rats, with the subsequent recording their weight gain caused by the administration of anabolic steroid. The method is simple, sensitive and permits to use the animals of different weight and sex without subjecting them to castration.

摘要

作者测试了一种新的生物学模型,用于定量测定长效甾烷醇的合成代谢作用。该方法的原理是在大鼠中切断比目鱼肌和跖肌协同肌——腓肠肌的肌腱后,造成小腿骨骼肌(比目鱼肌和跖肌)的孤立性超负荷,随后记录给予合成代谢类固醇后它们的体重增加情况。该方法简单、灵敏,允许使用不同体重和性别的动物,而无需对它们进行阉割。

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