[脑胶质瘤生长过程中对肿瘤相关抗原的免疫致敏作用（实验研究）]

[Immunologic sensitization to tumor-associated antigens during the growth of gliomas of the brain (experimental study)].

作者信息

Novichenko N L, Romodanov A P, Zhmareva E N, Gorovoĭ A I

出版信息

Zh Vopr Neirokhir Im N N Burdenko. 1984 Mar-Apr(2):9-13.

Abstract

The reactions of cellular immunity to malignant gliomas of the rat brain were studied by measuring the electrophoretic mobility of indicator cells (the EPM test). The appearance of sensitization coincided in time with the development of the glioma's own vascular network possessing no barrier function. The sensitization was constant in character and persisted till the death of the tumor-carriers. The EPM test did not reveal qualitative differences in sensitization in intracerebral and subcutaneous glioma growth.

摘要

通过测量指示细胞的电泳迁移率（EPM试验），研究了大鼠脑恶性胶质瘤的细胞免疫反应。致敏的出现与无屏障功能的胶质瘤自身血管网络的发育在时间上相吻合。致敏具有持续性，一直持续到荷瘤动物死亡。EPM试验未揭示脑内和皮下胶质瘤生长致敏的定性差异。