Hallengren B, Melander A, Thesleff S
Acta Endocrinol (Copenh). 1984 Jul;106(3):336-7. doi: 10.1530/acta.0.1060336.
Propylthiouracil (PTU) and propranolol can suppress, while methimazole (MMI) can enhance, mitogenic activation of lymphocytes. The present study investigated whether this effect of PTU, as has been shown for propranolol, relates to local anaesthetic activity. MMI (1 mM) but not PTU (1 mM) reduced the action potential in rat skeletal muscle. Thus, PTU seems to lack local anaesthetic activity. Moreover, the recorded local anaesthetic capacity of MMI hardly explains the stimulatory influence of MMI on lymphocyte activation. Apparently, the interference of MMI and PTU with lymphocyte activation seems to be due to another mechanism than local anaesthetic activity.
丙硫氧嘧啶（PTU）和普萘洛尔可抑制淋巴细胞的有丝分裂活化，而甲巯咪唑（MMI）则可增强这种活化。本研究调查了PTU的这种作用（如已在普萘洛尔中显示的那样）是否与局部麻醉活性有关。1 mM的MMI可降低大鼠骨骼肌的动作电位，但1 mM的PTU则无此作用。因此，PTU似乎缺乏局部麻醉活性。此外，所记录的MMI的局部麻醉能力很难解释其对淋巴细胞活化的刺激作用。显然，MMI和PTU对淋巴细胞活化的干扰似乎是由局部麻醉活性以外的另一种机制引起的。
