甲泛葡胺对大鼠局部脑葡萄糖代谢的影响。
The effect of metrizamide on regional brain glucose metabolism in the rat.
作者信息
Bech L, Diemer N H, Gjedde A
出版信息
Acta Neurol Scand. 1984 Apr;69(4):249-53. doi: 10.1111/j.1600-0404.1984.tb07808.x.
Abstract
The X-ray contrast material metrizamide is structurally related to 2-deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo, the present autoradiographic study with labeled 2-deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.
摘要
X射线造影剂甲泛葡胺在结构上与2-脱氧葡萄糖相关，且在体外可抑制脑葡萄糖磷酸化。在体内，本项使用标记的2-脱氧葡萄糖的放射自显影研究显示，给大鼠脑池内注射甲泛葡胺后，脑葡萄糖磷酸化出现整体降低。所有区域的降低平均为18%。
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