Aoyama K, Terashima K, Imai Y, Katsushima N, Okuyama Y, Niikawa K, Mukada T, Takahashi K
Acta Pathol Jpn. 1984 Mar;34(2):375-88. doi: 10.1111/j.1440-1827.1984.tb07565.x.
The present paper deals with immunohistochemical and ultrastructural study of the lymph nodes of sinus histiocytosis with massive lymphadenopathy (Rosai and Dorfman, SHML) of a 12-year-old Japanese boy. This is the fourth case in Japan. Osseous manifestation was also found in the bilateral ulnae. With hallmarks of S-100 protein and interdigitating cytoplasmic extensions, the phagocytizing histiocytes proliferating in the sinuses were considered to be derived mostly from interdigitating cells in the paracortex or T cell dependent area, which have heretofore been regarded as nonphagocytizing. Furthermore, it is most interesting that lymphoid cells bearing thymic cortical cell-antigen (OKT 6) were increasingly recognized in the patient's peripheral blood. These results suggested that SHML is a specialized reactive histiocytosis analogous to histiocytosis X and histiocytic medullary reticulosis.
本文对一名12岁日本男孩的伴有巨大淋巴结病的窦性组织细胞增生症（Rosai和Dorfman病，SHML）的淋巴结进行了免疫组织化学和超微结构研究。这是日本的第四例病例。在双侧尺骨中也发现了骨表现。在窦中增殖的吞噬组织细胞具有S-100蛋白和指状细胞质延伸的特征，被认为主要源自副皮质区或T细胞依赖区的指状细胞，而这些细胞迄今被认为不具有吞噬作用。此外，最有趣的是在患者外周血中越来越多地识别出带有胸腺皮质细胞抗原（OKT 6）的淋巴细胞。这些结果表明SHML是一种类似于组织细胞增多症X和组织细胞性髓性网状细胞增生症的特殊反应性组织细胞增生症。
