肾神经刺激对肾小管-肾小球反馈机制活性的影响。

Effect of renal nerve stimulation on the activity of the tubuloglomerular feedback mechanism.

作者信息

Hermansson K, Källskog O, Wolgast M

出版信息

Acta Physiol Scand. 1984 Mar;120(3):381-5. doi: 10.1111/j.1748-1716.1984.tb07398.x.

DOI:10.1111/j.1748-1716.1984.tb07398.x

Abstract

The influence of renal nerve stimulation on the tubuloglomerular feedback mechanism was studied on anaesthetized rats. The analyses was made by comparing the single-glomerular filtration rate (SNGFR) measured from late proximal tubules with SNGFR measured from distal tubules in the same nephron. In the former situation the flow to the macula densa cells is interrupted and in the latter the macula densa is influenced by the flow passing by. In the control situation the SNGFR measured proximally was 47.7 +/- 2.2 nl . min-1 (mean +/- SE) and 40.1 +/- 1.8 measured distally indicating an activated tubuloglomerular feedback. During renal nerve stimulation (2-3 Hz), the SNGFR fell to 38.5 +/- 2.3 and 33.5 4/- 1.7 when measured proximally and distally, respectively. The results indicate that the tubuloglomerular feedback mechanism is unaffected by renal nerve stimulation.

摘要

在麻醉大鼠身上研究了肾神经刺激对肾小管-肾小球反馈机制的影响。通过比较在同一肾单位中从近端小管晚期测得的单肾小球滤过率（SNGFR）与从远端小管测得的SNGFR进行分析。在前一种情况下，致密斑细胞的血流被中断，而在后一种情况下，致密斑受流经的血流影响。在对照情况下，近端测得的SNGFR为47.7±2.2 nl·min⁻¹（平均值±标准误），远端测得的为40.1±1.8，表明肾小管-肾小球反馈被激活。在肾神经刺激（2 - 3 Hz）期间，近端和远端测得的SNGFR分别降至38.5±2.3和33.5±1.7。结果表明，肾小管-肾小球反馈机制不受肾神经刺激的影响。