慢性低胆固醇血症在骨髓增殖性疾病中对血浆和红细胞生育酚分布的影响。

The effect of chronic hypocholesterolemia in myeloproliferative disease on the distribution of plasma and erythrocyte tocopherol.

作者信息

Gilbert H S, Stump D D, Ginsberg H, Roth E F

出版信息

Am J Clin Nutr. 1984 Jul;40(1):95-100. doi: 10.1093/ajcn/40.1.95.

DOI:10.1093/ajcn/40.1.95

Abstract

The presence of hypocholesterolemia and increased erythrocyte lipid peroxidation susceptibility in myeloproliferative disorders raised the possibility of coexistent tocopherol deficiency. Plasma and red blood cell (RBC) alpha-tocopherol, beta- + gamma-tocopherol, and free cholesterol were determined simultaneously by high performance liquid chromatography in 22 patients and 26 controls. Plasma alpha-tocopherol was correlated most highly with plasma free cholesterol and secondarily with RBC alpha-tocopherol in both groups. Plasma-free cholesterol and alpha-tocopherol were significantly reduced in myeloproliferative disease, although the ratio between the two remained normal. Erythrocyte tocopherol and free cholesterol concentrations were normal in myeloproliferative disease. High relative retention of tocopherol by erythrocytes was most pronounced in patients with the lowest plasma alpha-tocopherol and free cholesterol levels. The normal RBC tocopherol levels in these patients with chronic hypocholesterolemia indicate that the observed increase in RBC peroxidation susceptibility is not explainable by a deficiency of RBC vitamin E.

摘要

骨髓增殖性疾病中存在低胆固醇血症以及红细胞脂质过氧化易感性增加，这提示了同时存在生育酚缺乏的可能性。采用高效液相色谱法同时测定了22例患者和26例对照者的血浆及红细胞（RBC）α-生育酚、β + γ-生育酚和游离胆固醇。在两组中，血浆α-生育酚与血浆游离胆固醇的相关性最高，其次与RBCα-生育酚相关。骨髓增殖性疾病患者的血浆游离胆固醇和α-生育酚显著降低，尽管二者之间的比例仍保持正常。骨髓增殖性疾病患者的红细胞生育酚和游离胆固醇浓度正常。红细胞对生育酚的高相对保留率在血浆α-生育酚和游离胆固醇水平最低的患者中最为明显。这些慢性低胆固醇血症患者的红细胞生育酚水平正常，表明所观察到的红细胞过氧化易感性增加不能用红细胞维生素E缺乏来解释。