Effects of quipazine on behavior under a multiple schedule of reinforcement.

The effects of three doses of quipazine (1.0, 5.0 and 10.0 mg/kg) on the performance of rats under a multiple fixed-ratio 15 fixed-interval 60-sec schedule of food reinforcement were examined. In the absence of drug, response rates under the fixed-ratio component were much higher than response rates under the fixed-interval component. Rates under the fixed-ratio component were decreased by quipazine in dose-dependent fashion, while response rates under the fixed-interval component were increased by the lowest dose and decreased by the two higher doses of the drug.