细胞外钙和细胞内钙对灌注大鼠肝脏中α-肾上腺素能激动剂作用的贡献。
The contribution of both extracellular and intracellular calcium to the action of alpha-adrenergic agonists in perfused rat liver.
作者信息
Reinhart P H, Taylor W M, Bygrave F L
出版信息
Biochem J. 1984 May 15;220(1):35-42. doi: 10.1042/bj2200035.
Abstract
The role of both intracellular and extracellular Ca2+ pools in the expression of alpha-adrenergic-agonist-mediated responses was examined in perfused rat liver. Responses studied included glycogenolysis, respiration, lactate and pyruvate formation, ketone-body production, changes in the cytoplasmic and mitochondrial redox ratio and cellular K+ fluxes. Each of these was shown to be dependent on the mobilization of intracellular Ca2+ and can be grouped into one of two response types. Transient responses (ion fluxes and the redox ratios) are obligatorily dependent on the mobilization of intracellular Ca2+ and occur irrespective of the extracellular Ca2+ concentration. Sustained responses, on the other hand, initially require intracellular Ca2+ and, subsequently, extracellular Ca2+. The data indicate that alpha-adrenergic agonists mobilize extracellular Ca2+ as well as intracellular Ca2+ and that both pools are required for the full expression of hormone-induced responses in rat liver.
摘要
在灌注的大鼠肝脏中，研究了细胞内和细胞外钙库在α-肾上腺素能激动剂介导反应表达中的作用。所研究的反应包括糖原分解、呼吸作用、乳酸和丙酮酸生成、酮体产生、细胞质和线粒体氧化还原比值的变化以及细胞钾离子通量。结果表明，这些反应均依赖于细胞内钙离子的动员，并且可分为两种反应类型之一。瞬时反应（离子通量和氧化还原比值）必然依赖于细胞内钙离子的动员，且无论细胞外钙离子浓度如何都会发生。另一方面，持续反应最初需要细胞内钙离子，随后需要细胞外钙离子。数据表明，α-肾上腺素能激动剂可动员细胞外钙离子以及细胞内钙离子，并且这两个钙库都是大鼠肝脏中激素诱导反应充分表达所必需的。
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A kinetic analysis of the effects of adrenaline on calcium distribution in isolated rat liver parenchymal cells.肾上腺素对离体大鼠肝实质细胞钙分布影响的动力学分析。
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Role of calcium in the hormonal regulation of liver metabolism.钙在肝脏代谢激素调节中的作用。
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