甲状腺球蛋白mRNA的水平在体外和体内均受促甲状腺激素（TSH）的调节。
The level of thyroglobulin mRNA is regulated by TSH both in vitro and in vivo.
作者信息
Avvedimento V E, Tramontano D, Ursini M V, Monticelli A, Di Lauro R
出版信息
Biochem Biophys Res Commun. 1984 Jul 18;122(1):472-7. doi: 10.1016/0006-291x(84)90500-x.
PMID:6743348
Abstract
We have studied the effect of thyrotropin on the intracellular concentration of thyroglobulin and of its mRNA both in a differentiated rat thyroid cell line and in the rat thyroid in vivo. Our data demonstrate that the absence of thyrotropin causes a two fold decrease of both thyroglobulin and of its mRNA suggesting that thyroglobulin synthesis in thyroid cells is 50% constitutive.
摘要
我们研究了促甲状腺激素对分化的大鼠甲状腺细胞系以及体内大鼠甲状腺中甲状腺球蛋白及其mRNA细胞内浓度的影响。我们的数据表明，促甲状腺激素的缺失导致甲状腺球蛋白及其mRNA均下降两倍，这表明甲状腺细胞中甲状腺球蛋白的合成有50%是组成性的。
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