No detectable concentrations of oxmetidine but measurable concentrations of cimetidine in cerebrospinal fluid (CSF) during multiple dose treatment.
作者信息
Jönsson K A, Eriksson S E, Kagevi I, Norlander B, Bodemar G, Walan A
出版信息
Br J Clin Pharmacol. 1984 Jun;17(6):781-2. doi: 10.1111/j.1365-2125.1984.tb02420.x.
Abstract
摘要
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No detectable concentrations of oxmetidine but measurable concentrations of cimetidine in cerebrospinal fluid (CSF) during multiple dose treatment.多次给药治疗期间，脑脊液（CSF）中未检测到奥美替丁浓度，但可检测到西咪替丁浓度。
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Cimetidine, but not oxmetidine, penetrates into the cerebrospinal fluid after a single intravenous dose.西咪替丁单次静脉给药后可穿透进入脑脊液，而奥美替丁则不能。
Br J Clin Pharmacol. 1982 Dec;14(6):815-9. doi: 10.1111/j.1365-2125.1982.tb02042.x.
2
The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function.西咪替丁及其亚砜代谢产物在肾功能正常和受损患者中的药代动力学。
Br J Clin Pharmacol. 1982 Feb;13(2):163-70. doi: 10.1111/j.1365-2125.1982.tb01351.x.
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Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values.神经系统疾病中白蛋白和免疫球蛋白G分析的原则。I. 参考值的确定。
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The effect of cimetidine, a new histamine H2-receptor antagonist, on renal function.
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