钐作为研究分离的豚鼠腹侧结肠带对钡反应性的工具。

Samarium as a tool in studies on the responsiveness of the isolated guinea pig ventral taenia coli to barium.

作者信息

Turrin M Q

出版信息

Pharmacology. 1978;16(6):301-5. doi: 10.1159/000136785.

Abstract

The responsiveness of isolated guinea pig ventral taenia coli to barium in polarized (Ringer-Tris medium) and depolarized (Ringer-KCl medium) preparations was assayed in the presence of samarium (Sm3+, 6 or 8 X 10(5) M). No difference in EC50 or maximal response was observed between polarized and depolarized preparations (p greater than 0.05). The lower Sm3+ concentration increased Ba2+ EC50 in both experimental conditions (p less than 0.05) although no alteration was observed as to the maximal response (p greater than 0.05). On the other hand, maximal tension was strongly reduced by the higher Sm3+ concentration in polarized preparations (p less than 0.01) while a potentiation of the maximum response was observed on the depolarized tissues (p less than 0.05). A possible role for calcium ions in the mediation of the effects is suggested.

摘要

在钐（Sm3+，6或8×10⁻⁵ M）存在的情况下，测定了分离的豚鼠腹侧结肠带在极化（林格 - Tris培养基）和去极化（林格 - KCl培养基）制剂中对钡的反应性。在极化和去极化制剂之间未观察到EC50或最大反应的差异（p>0.05）。较低的Sm3+浓度在两种实验条件下均增加了Ba2+的EC50（p<0.05），尽管未观察到最大反应的改变（p>0.05）。另一方面，较高的Sm3+浓度在极化制剂中强烈降低了最大张力（p<0.01），而去极化组织上观察到最大反应增强（p<0.05）。提示了钙离子在介导这些效应中可能的作用。