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[EL-4小鼠淋巴瘤神经节苷脂的结构]

[Structure of lymphoma gangliosides in EL-4 mice].

作者信息

Diatlovitskaia E V, Fomina-Ageeva E V, Volgin Iu V, Sadovskaia V L, Kogtev L S

出版信息

Biokhimiia. 1984 May;49(5):707-11.

PMID:6743700
Abstract

The structure of the major gangliosides from murine lymphoma EL-4 was established by acid hydrolysis, methanolysis, methylation analysis, neuraminidase treatment and chromium trioxide oxidation. Two of these gangliosides were identified as the N-acetyl and N-glycoloyl forms of the GM2 ganglioside. The third ganglioside making up to 40% of the total ganglioside pool contained two sialic acid residues and was identified as a GD2 ganglioside which up to now had not been reported in extraneural tissues.

摘要

通过酸水解、甲醇解、甲基化分析、神经氨酸酶处理和三氧化铬氧化确定了来自小鼠淋巴瘤EL-4的主要神经节苷脂的结构。其中两种神经节苷脂被鉴定为GM2神经节苷脂的N-乙酰基和N-糖基化形式。构成总神经节苷脂库40%的第三种神经节苷脂含有两个唾液酸残基,被鉴定为GD2神经节苷脂,迄今为止尚未在神经外组织中报道过。

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