Kuznetsov I G, Slutskiĭ L I, Suslova S K, Gol'dberg O A, Voronkov M G
Biull Eksp Biol Med. 1984 Jun;97(6):658-60.
It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.
在患有实验性胃溃疡的大鼠中已证实，1-（氯甲基）硅氮烷可增强肉芽-纤维组织的发育，并有利于优化胶原蛋白和糖胺聚糖（主要的结缔组织生物聚合物）的比例。此外，与甲基尿嘧啶和氧化亚铁碳相比，1-（氯甲基）硅氮烷对溃疡组织中含己糖胺的糖蛋白产生更显著的影响。同时，从唾液蛋白的时间进程判断，抗溃疡药物甲基尿嘧啶和氧化亚铁碳比1-（氯甲基）硅氮烷是更有效的抗炎剂。
