Selzer M E, David G, Yaari Y
Brain Res. 1984 Jun 18;304(1):149-52. doi: 10.1016/0006-8993(84)90871-0.
The action of the commonly used antiepileptic drug phenytoin on frequency potentials was studied at the frog neuromuscular junction. Whereas the drug, at concentrations of 0.1-0.3 mM, had only a slight effect on EPPs evoked by nerve stimulation at a frequency of 0.5 Hz, it strongly suppressed their potentiation during tetanic nerve stimulation at 30 Hz. The post-tetanic potentiation of the EPPs was also reduced by the drug. These effects occurred without a blockade of invasion of the nerve impulse into the presynaptic terminal during the tetanus, and thus indicate a specific frequency-dependent depressant action of the drug on neurally-evoked transmitter release.
在青蛙神经肌肉接头处研究了常用抗癫痫药物苯妥英对频率电位的作用。在浓度为0.1 - 0.3 mM时，该药物对0.5 Hz频率的神经刺激诱发的终板电位（EPPs）仅有轻微影响，但在30 Hz强直神经刺激期间却强烈抑制其增强。该药物还降低了EPPs的强直后增强。这些效应发生时，并未阻断破伤风期间神经冲动侵入突触前终末，因此表明该药物对神经诱发的递质释放具有特定的频率依赖性抑制作用。
