Nicholas J F, Lam A M
Can Anaesth Soc J. 1984 Jul;31(4):352-8. doi: 10.1007/BF03015401.
Induced hypotension during anaesthesia can result in deterioration in gas exchange with increases in intrapulmonary shunting and physiological deadspace. Cardiovascular stability has been previously demonstrated with isoflurane-induced hypotension but the effects on gas exchange have not been carefully studied. We have examined the shunt fraction (QS/QT) and physiological dead space to tidal volume ratio (VD/VT) before, during and following deliberate hypotension in twelve patients. Group I (n = 6) received an isoflurane-oxygen-air mixture with an FIO2 of 0.5 while Group II (n = 6) received an isoflurane-oxygen mixture with an FIO2 of 1.0. Mean blood pressure was reduced from 76 +/- 2 mmHg to 47 +/- 2 mmHg in the combined group. Neither QS/QT nor VD/VT changed significantly during the hypotensive state in either group. We conclude that isoflurane induced hypotension is associated with minimal pulmonary derangement.
麻醉期间诱导性低血压可导致气体交换恶化，肺内分流和生理死腔增加。先前已证明异氟烷诱导性低血压时心血管系统的稳定性，但对气体交换的影响尚未得到仔细研究。我们检查了12例患者在控制性低血压之前、期间和之后的分流分数（QS/QT）和生理死腔与潮气量之比（VD/VT）。第一组（n = 6）接受FIO2为0.5的异氟烷-氧气-空气混合物，而第二组（n = 6）接受FIO2为1.0的异氟烷-氧气混合物。联合组平均血压从76±2 mmHg降至47±2 mmHg。两组在低血压状态下QS/QT和VD/VT均无显著变化。我们得出结论，异氟烷诱导性低血压与最小程度的肺部紊乱有关。
