Richard D, Trayhurn P
Can J Physiol Pharmacol. 1984 Jun;62(6):695-9. doi: 10.1139/y84-114.
The present study has investigated the respective effects of training and exercise on the rates of fatty acid synthesis in mice. Male C57B1 10ScSn mice were trained by forced swimming in a tank at 36 degrees C for 2 h each day for a 28-day period. Rates of fatty acid synthesis were determined in vivo by measuring the incorporation of tritium from 3H2O into tissue fatty acids. At the end of the training programme, both sedentary and trained mice were assigned to either exercising or resting groups. The results obtained show that both training and exercise affected the rates of fatty acid synthesis, regardless of whether the results are expressed per gram of tissue or per whole tissue. Training led to significant decreases in the rates of synthesis in the liver, interscapular brown adipose tissue, epididymal white adipose tissue, and the remaining carcass, particularly in resting mice. The rates of fatty acid synthesis in the major lipogenic tissues were also lower during exercise than under sedentary conditions. The reduction in synthesis in brown adipose tissue was noteworthy in view of the high capacity of this tissue for fatty acid synthesis. In conclusion, it is suggested that in exercise-trained mice carbohydrate is shunted away from the synthesis of lipid in favour of energy storage as glycogen.
本研究调查了训练和运动对小鼠脂肪酸合成速率的各自影响。雄性C57B1 10ScSn小鼠在36摄氏度的水箱中每天强迫游泳2小时，持续28天进行训练。通过测量3H2O中的氚掺入组织脂肪酸的情况来体内测定脂肪酸合成速率。在训练计划结束时，将久坐不动的小鼠和经过训练的小鼠都分为运动组或休息组。获得的结果表明，无论结果是以每克组织还是以整个组织来表示，训练和运动都影响脂肪酸合成速率。训练导致肝脏、肩胛间棕色脂肪组织、附睾白色脂肪组织和其余胴体的合成速率显著降低，尤其是在休息的小鼠中。运动期间主要生脂组织中的脂肪酸合成速率也比久坐不动的条件下低。鉴于棕色脂肪组织具有很高的脂肪酸合成能力，其合成的减少值得注意。总之，建议在经过运动训练的小鼠中，碳水化合物从脂质合成中分流，转而有利于作为糖原的能量储存。
