Recent advances in histamine research: closing remarks.

In an attempt to highlight some of the more interesting problems of current histamine research several issues have been considered, including the difficulty of finding selective drugs, particularly agonists, the problems of receptor and organ selectivity, and the mystery of the biological function of histamine receptors in smooth muscle. These problems were raised in one form or another by speakers at this symposium and it is clear that despite the many exciting advances reported in the earlier communication many mysteries remain.