扎伊德拉腹水肝癌对荷瘤大鼠肝脏组氨酸酶活性及合成的影响。
Effect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats.
作者信息
Fedorov S A, Khasigov P Z
出版信息
Cancer Lett. 1984 May;23(1):67-71. doi: 10.1016/0304-3835(84)90063-6.
PMID:6744236
Abstract
The synthesis of histidase occurs only in free polyribosomes. The relative content of histidase synthesizing polyribosomes in rat liver, in Zajdela ascites hepatoma cells and in the liver of tumor-bearing rats is equal to 1.35%, 0.11% and 0.57%, respectively (of the total amount of free polyribosomes). It was found that hepatoma cell sap has an inhibitory effect on the synthesis of proteins in the cell-free system reconstructed from polyribosomes and cell sap of control rats.
摘要
组氨酸酶仅在游离多核糖体中合成。大鼠肝脏、扎伊德拉腹水肝癌细胞以及荷瘤大鼠肝脏中合成组氨酸酶的多核糖体的相对含量分别为（游离多核糖体总量的）1.35%、0.11%和0.57%。研究发现，肝癌细胞液对由对照大鼠的多核糖体和细胞液重建的无细胞系统中的蛋白质合成具有抑制作用。
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