1,1-二乙基-3-甲基-3-亚硝基脲对叙利亚金黄地鼠的致癌作用。
The carcinogenic effect of 1,1-diethyl-3-methyl-3-nitrosourea in Syrian golden hamsters.
作者信息
Ketkar M B, Mohr U, Lijinsky W
出版信息
Cancer Lett. 1984 Jun;23(2):177-82. doi: 10.1016/0304-3835(84)90151-4.
PMID:6744242
Abstract
1,1-Diethyl-3-methyl-3-nitrosourea (Et2MNU) was subcutaneously injected in Syrian golden hamsters once weekly for 52 weeks. The animals developed mainly papillomas and squamous cell carcinomas of the nasal cavity and forestomach and hemangioendotheliomas of the spleen. Although survival time and tumour latency showed dose-dependency, tumour incidence did not.
摘要
1,1-二乙基-3-甲基-3-亚硝基脲（Et2MNU）每周一次皮下注射叙利亚金黄地鼠，持续52周。这些动物主要发生鼻腔和前胃的乳头状瘤和鳞状细胞癌以及脾脏的血管内皮瘤。虽然生存时间和肿瘤潜伏期显示出剂量依赖性，但肿瘤发生率并非如此。
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