Tullis D L, Banerjee S
Cancer Lett. 1984 Jul;23(3):241-4. doi: 10.1016/0304-3835(84)90089-2.
It is hypothesized that differences in the carcinogenicity of certain aza-arenes and their carbocyclic analogs may originate from the ability of the former to form covalent hydrates. The hypothesis is primarily based on a comparison of the carcinogenicity of several aza-arenes with that of corresponding carbocyclic compounds and of aromatic amines which are structurally related to the hydrated aza-arenes. Additional evidence is provided by the regiochemistry of cytochrome P-450 catalyzed oxidation of quinoline.
据推测，某些氮杂芳烃及其碳环类似物致癌性的差异可能源于前者形成共价水合物的能力。该假设主要基于几种氮杂芳烃与相应碳环化合物以及与水合氮杂芳烃结构相关的芳香胺的致癌性比较。细胞色素P - 450催化喹啉氧化的区域化学提供了额外的证据。
