Hoogendoorn H A, Renooij W, Akkermans L M, Visser W, Wittebol P
Clin Orthop Relat Res. 1984 Jul-Aug(187):281-8.
Blocks of porous ceramic hydroxyapatite (dimensions, 2.5 X 1.25 X 0.5 cm; sintering temperature, 1300 degrees; macroporosity, 56%; average pore size 0.18 mm2) were implanted into surgically created defects in dog femora. The implants were retrieved up to 3.5 years after implantation. The implants were 3.5 years after implantation. The implants were firmly attached to the bone. Histologic evaluation suggests that optimal contact between bone and implant should be provided to accelerate bone ingrowth. Bone growth in the pores reached a maximum level after 35 weeks, at which time about one-third of the pore space was filled with bone. When measuring the relative surface areas of bone and ceramic on histologic slides, no change in ceramic mass could be detected, indicating that hydroxyapatite ceramics are not affected by biodegradation processes. The implants effectively provided a scaffold for bone growth bridging a larger bone defect.
将多孔陶瓷羟基磷灰石块（尺寸为2.5×1.25×0.5厘米；烧结温度为1300度；大孔隙率为56%；平均孔径为0.18平方毫米）植入犬股骨手术造成的缺损处。植入后长达3.5年取出植入物。植入物在植入后3.5年。植入物与骨牢固附着。组织学评估表明，应提供骨与植入物之间的最佳接触以加速骨长入。孔隙中的骨生长在35周后达到最高水平，此时约三分之一的孔隙空间被骨填充。在组织学切片上测量骨和陶瓷的相对表面积时，未检测到陶瓷质量的变化，表明羟基磷灰石陶瓷不受生物降解过程的影响。植入物有效地为骨生长提供了支架，桥接了较大的骨缺损。
