Bansal M B, Chuah S K, Thadepalli H
Chemotherapy. 1984;30(4):237-43. doi: 10.1159/000238274.
In vitro susceptibility of 473 isolates of anaerobic bacteria derived from patients hospitalized for treatment of abdominal trauma was tested against third-generation cephalosporins--moxalactam, cefotaxime, ceftizoxime, cefmenoxime--and a penicillin--N-formimidoyl thienamycin--by serial agar dilution method in the anaerobic glove box. There were 208 Bacteroides isolates including 80 Bacteroides fragilis and 100 peptococci and peptostreptococci. The minimal inhibitory concentration (MIC) 75% of B. fragilis was less than or equal to 32 micrograms/ml for the cephalosporins tested and less than or equal to 8 micrograms/ml for thienamycin. The MIC of B. fragilis and Bacteroides vulgatus was not much influenced by increased inoculum size. Characteristically, peptostreptococci and peptococci were resistant to all four cephalosporins tested with MIC 75% being 32-64 micrograms/ml. All five antibiotics in this study appear suitable for therapy of intraabdominal suppurative infections, but the poor activity of third-generation cephalosporins on anaerobic cocci can be a cause of concern.
采用连续琼脂稀释法，在厌氧手套箱中对473株从因腹部创伤住院治疗的患者体内分离出的厌氧菌进行了体外药敏试验，受试药物为第三代头孢菌素——莫西拉坦、头孢噻肟、头孢唑肟、头孢甲肟——以及一种青霉素——N-甲酰亚胺硫霉素。其中有208株拟杆菌分离株，包括80株脆弱拟杆菌以及100株消化球菌和消化链球菌。对于受试的头孢菌素，脆弱拟杆菌的最低抑菌浓度（MIC）75%小于或等于32微克/毫升，对于硫霉素则小于或等于8微克/毫升。接种量增加对脆弱拟杆菌和普通拟杆菌的MIC影响不大。典型的是，消化链球菌和消化球菌对所有四种受试头孢菌素均耐药，MIC 75%为32 - 64微克/毫升。本研究中的所有五种抗生素似乎都适合用于治疗腹腔内化脓性感染，但第三代头孢菌素对厌氧球菌活性较差可能令人担忧。
