人低分子量激肽原。轻链的氨基酸序列；与其他蛋白质序列的同源性。

Human low-molecular-mass kininogen. Amino-acid sequence of the light chain; homology with other protein sequences.

作者信息

Lottspeich F, Kellermann J, Henschen A, Rauth G, Müller-Esterl W

出版信息

Eur J Biochem. 1984 Jul 16;142(2):227-32. doi: 10.1111/j.1432-1033.1984.tb08275.x.

DOI:10.1111/j.1432-1033.1984.tb08275.x

Abstract

The complete amino acid sequence of the human low-molecular-mass kininogen light chain has been determined. The peptide chain contains 38 amino acid residues. In position 18 the half-cystine residue which forms the disulfide bridge to the heavy chain was found. Alignment of the present sequence with other kininogen light chain sequences indicated that the amino-terminal part of it is species-specific and the carboxy-terminal part is function-specific. Statistically significant internal homologies between various parts of the low-molecular-mass kininogen sequence as well as homologies between parts of the sequences of kininogen and ribonucleases were observed.

摘要

人低分子量激肽原轻链的完整氨基酸序列已被确定。肽链包含38个氨基酸残基。在第18位发现了与重链形成二硫键的半胱氨酸残基。将本序列与其他激肽原轻链序列进行比对表明，其氨基末端部分具有物种特异性，而羧基末端部分具有功能特异性。观察到低分子量激肽原序列不同部分之间具有统计学意义的内部同源性，以及激肽原序列与核糖核酸酶序列部分之间的同源性。