Hara N, Furukawa T, Yoshida T, Inokuchi K
Eur Surg Res. 1984;16(4):214-9. doi: 10.1159/000128411.
We demonstrated the effect of hemorrhagic shock with resuscitation on pulmonary fluid and protein exchange in anesthetized dogs. Lung lymph flow decreased during early shock and then increased gradually to baseline during late shock as the pulmonary vascular pressures reverted toward baseline levels, while the lymph-to-plasma protein ratio remained relatively constant throughout the shock period. During resuscitation, lung lymph flow increased significantly with the decreasing lymph:plasma protein ratio, suggesting no change in permeability to proteins. Lymph protein flow, which is characteristic of increased endothelial permeability, was also not altered during resuscitation, compared to that following increased vascular pressure induced by inflation of a left atrial balloon catheter. These findings suggest that no change in pulmonary vascular permeability occurs in anesthetized dogs after hemorrhagic shock with resuscitation.
我们在麻醉犬中证明了失血性休克复苏对肺液体和蛋白质交换的影响。在休克早期，肺淋巴流量减少，而在休克后期，随着肺血管压力恢复至基线水平，肺淋巴流量逐渐增加至基线，而在整个休克期，淋巴-血浆蛋白比值保持相对恒定。在复苏过程中，肺淋巴流量显著增加，同时淋巴：血浆蛋白比值降低，提示蛋白质通透性未发生改变。与左心房球囊导管充气诱导血管压力升高后相比，复苏期间内皮通透性增加所特有的淋巴蛋白流量也未改变。这些发现表明，失血性休克复苏后的麻醉犬肺血管通透性未发生改变。
