Hattner R S, Margulis A R, Skioldebrand K C, Hartmeyer J, Stoughton J
Eur Surg Res. 1984;16(4):238-41. doi: 10.1159/000128414.
A method of quantitation of mucin using chondroitin sulfate A as a standard has been modified and applied to timed mucin collections from surgically created isolated colonic fistulas in 8 dogs. 25 experiments were conducted in which the effect of secretin was tested in 5. The mucin assay is precise and showed increased colonic mucin secretin in response to secretin. This model appears suitable for pharmacologic assessment of potential drugs for augmenting colonic mucin secretin in states of impaired colonic motility.
一种以硫酸软骨素A为标准定量黏蛋白的方法已得到改进，并应用于对8只犬手术制造的孤立结肠瘘定时收集的黏蛋白。进行了25项实验，其中5项测试了促胰液素的作用。黏蛋白测定精确，显示结肠黏蛋白分泌量对促胰液素增加有反应。该模型似乎适用于对潜在药物进行药理学评估，这些药物用于增强结肠运动功能受损状态下的结肠黏蛋白分泌。
