Gemba H, Sasaki K
Exp Brain Res. 1984;55(1):26-32. doi: 10.1007/BF00240495.
A monkey was trained to lift a lever by wrist extension in response to a light stimulus. During the learning process of the task over several months, field potentials related not only to the task performance but also to substitution and stimulation experiments were recorded with chronically implanted electrodes on the surface and at a depth of 2.5-3.0 mm in the prefrontal, premotor, motor and prestriate cortices. In the substitution experiment, an examiner lifted a lever for the monkey so that it was watching the light and rewarded without the hand movement. In the stimulation experiment, the same light stimulus was simply delivered to the monkey. In a naive monkey which lifted the lever independently of the stimulus, stimulus-locked potentials were evoked by the task experiment in those cortices except the motor cortex, but none was elicited by the substitution or stimulation experiment. In a well-trained monkey, the substitution and stimulation experiments induced almost the same potentials as those prior to the task movement in respective cortices except the motor cortex, in which the component of cerebellar-induced premovement potential was not observed during the substitution and stimulation experiments. At an intermediate stage of learning, the situation was intermediate between the naive and well-trained stages and most premovement potentials except those in the motor cortex were elicited by the substitution experiment in reduced sizes, but nothing by the stimulation experiment.(ABSTRACT TRUNCATED AT 250 WORDS)
训练一只猴子通过伸展手腕来抬起杠杆以对光刺激做出反应。在为期数月的任务学习过程中，使用长期植入的电极在额叶前部、运动前区、运动区和纹前皮质表面及2.5 - 3.0毫米深度记录与任务执行、替代和刺激实验相关的场电位。在替代实验中，检查人员为猴子抬起杠杆，使其观看灯光并在没有手部动作的情况下得到奖励。在刺激实验中，仅向猴子提供相同的光刺激。在一只独立于刺激抬起杠杆的未受过训练的猴子中，任务实验在除运动皮质外的那些皮质中诱发了刺激锁定电位，但替代或刺激实验未诱发任何电位。在一只训练有素的猴子中，替代和刺激实验在除运动皮质外的各个皮质中诱发的电位与任务运动前的电位几乎相同，在运动皮质中，替代和刺激实验期间未观察到小脑诱发的运动前电位成分。在学习的中间阶段，情况介于未受过训练和训练有素阶段之间，除运动皮质外的大多数运动前电位通过替代实验以较小的幅度诱发，但刺激实验未诱发任何电位。（摘要截于250字）
