Axelrod J H, Fruchter R, Boyce J G
Gynecol Oncol. 1984 Jul;18(3):359-72. doi: 10.1016/0090-8258(84)90048-9.
Seventy-eight synchronous or metachronous tumors among 2362 patients followed by the Downstate Gynecologic Tumor Registry are reviewed. Significant synchronous tumor pairs include cervix (invasive and in situ)-ovary, cervix (in situ)-uterus, cervix (in situ)-kidney, endometrium-ovary, endometrium-rectosigmoid, and ovary-breast. Significant metachronous pairs include cervix (invasive and in situ combined)-lung, cervix (invasive and in situ combined)-upper alimentary tract, and cervix (invasive)-rectosigmoid. In the case of in situ and invasive cervical cancer-lower genital tract, significance was determined for both synchronous and metachronous pairs. Long survival is an important factor in the appearance of a second tumor as demonstrated in patients with cervical carcinoma. Synchronous data prove to be valuable in assessing in risk of second primaries in patients surviving for short periods. The roles of cigarette smoking, hormones, immunosuppression, radiotherapy, and screening are discussed.
回顾了Downstate妇科肿瘤登记处随访的2362例患者中的78例同时性或异时性肿瘤。重要的同时性肿瘤对包括宫颈（浸润性和原位）-卵巢、宫颈（原位）-子宫、宫颈（原位）-肾、子宫内膜-卵巢、子宫内膜-直肠乙状结肠和卵巢-乳腺。重要的异时性肿瘤对包括宫颈（浸润性和原位合并）-肺、宫颈（浸润性和原位合并）-上消化道和宫颈（浸润性）-直肠乙状结肠。对于原位和浸润性宫颈癌-下生殖道，同时性和异时性肿瘤对均具有统计学意义。长期生存是出现第二种肿瘤的重要因素，如宫颈癌患者所示。同时性数据在评估短期存活患者发生第二原发性肿瘤的风险方面被证明是有价值的。讨论了吸烟、激素、免疫抑制、放疗和筛查的作用。
