Anversa P, Melissari M, Tardini A, Olivetti G
Hypertension. 1984 Jul-Aug;6(4):526-9. doi: 10.1161/01.hyp.6.4.526.
The left coronary artery of 21-, 28-, and 45-day-old spontaneously hypertensive rats and Wistar-Kyoto rats was analyzed morphometrically to evaluate the structural alterations of the vessel wall during the development of genetically determined hypertension. In 45-day-old rats, hypertension was associated with a significant expansion of the partial volume of collagen and ground substance (119%) within the arterial wall. This change exceeded the concurrent accumulation of elastin (77%) and smooth muscle cell mass (34%). The growth of the muscle compartment was also characterized by a marked increment of rough endoplasmic reticulum (103%). The increase in the mural concentration of fibrous proteins at this early age may be viewed as the initial adverse effect of hypertension on muscular arteries.
对21日龄、28日龄和45日龄的自发性高血压大鼠和Wistar-Kyoto大鼠的左冠状动脉进行形态计量学分析，以评估在遗传性高血压发展过程中血管壁的结构变化。在45日龄大鼠中，高血压与动脉壁内胶原蛋白和基质的部分体积显著增加（119%）有关。这种变化超过了同时期弹性蛋白的积累（77%）和平滑肌细胞质量的增加（34%）。肌肉成分的生长还表现为粗面内质网显著增加（103%）。在这个早期阶段，血管壁中纤维蛋白浓度的增加可被视为高血压对肌性动脉的初始不良影响。
