Pharmacokinetics of lidocaine in healthy individuals pretreated with multiple doses of metoprolol.

The effect of pretreatment with multiple doses of 100 mg of metoprolol on the pharmacokinetics of lidocaine has been studied in six young healthy subjects. The lidocaine dose was 100 mg and the infusion time 12 minutes. Metoprolol had no effect on the levels or the time course of lidocaine in the plasma. The disposition characteristics of the antiarrhythmic agent were not significantly altered by metoprolol in these individuals. These results cannot be extrapolated to prolonged infusion of lidocaine in patients with myocardial infarction.