Jordö L, Johnsson G, Lundborg P, Regårdh C G
Int J Clin Pharmacol Ther Toxicol. 1984 Jun;22(6):312-5.
The effect of pretreatment with multiple doses of 100 mg of metoprolol on the pharmacokinetics of lidocaine has been studied in six young healthy subjects. The lidocaine dose was 100 mg and the infusion time 12 minutes. Metoprolol had no effect on the levels or the time course of lidocaine in the plasma. The disposition characteristics of the antiarrhythmic agent were not significantly altered by metoprolol in these individuals. These results cannot be extrapolated to prolonged infusion of lidocaine in patients with myocardial infarction.
在六名年轻健康受试者中研究了多次给予100毫克美托洛尔预处理对利多卡因药代动力学的影响。利多卡因剂量为100毫克，输注时间为12分钟。美托洛尔对血浆中利多卡因的水平或时间进程没有影响。在这些个体中，美托洛尔并未显著改变抗心律失常药物的处置特征。这些结果不能外推至心肌梗死患者中利多卡因的长时间输注情况。
