Bridges C H, Womack J E, Harris E D, Scrutchfield W L
J Am Vet Med Assoc. 1984 Jul 15;185(2):173-8.
Of 8 Thoroughbred foals in which osteochondrosis developed before weaning, 7 had serum copper and ceruloplasmin concentrations below normal. Three foals on one farm had serum zinc content high enough to suggest zinc toxicosis, and the liver of each foal contained abnormally high content of zinc. Four foals from the second farm had extremely low serum copper content, but normal serum zinc content. Evidence of environmental exposure to excess zinc was not found on either farm. The lesions in the zones of endochondral ossification of the afflicted foals were similar in many respects to those found in other species of animals with molybdenum-induced copper deficiency and with inhibition of the function of copper-dependent lysyl oxidase by beta-aminopropionitrile, a toxic component of Lathyrus odoratus known to cause osteolathyrism.
在8匹断奶前就患上骨软骨病的纯种马驹中，7匹血清铜和铜蓝蛋白浓度低于正常水平。一个农场的3匹小马驹血清锌含量高到足以提示锌中毒，且每匹马驹的肝脏含锌量异常高。第二个农场的4匹小马驹血清铜含量极低，但血清锌含量正常。两个农场均未发现环境中存在过量锌暴露的证据。患病马驹软骨内成骨区的病变在许多方面与其他动物因钼诱导的铜缺乏以及香豌豆（已知会导致骨软病）的有毒成分β-氨基丙腈抑制铜依赖性赖氨酰氧化酶功能所发现的病变相似。
