Steele N C, Rosebrough R W, McMurtry J P
J Anim Sci. 1984 Jun;58(6):1388-95. doi: 10.2527/jas1984.5861388x.
Systemic ketosis was induced in first-parity gilts by the isocaloric substitution of glucose with 1,3-butylene glycol to supply 20% of the total dietary energy beginning on d 23 (23 BG) or d 60 (60 BG) of gestation. Ketosis reduced (P less than .05) maternal plasma glucose, urea N and insulin concentrations. Fetal carcass dry matter and carcass glycogen contents were reduced (P less than .05) by maternal ketogenic calorie substitution, whereas fetal hepatic glycogen and lipid contents were not influenced by maternal treatment. Neural acetate oxidation was reduced (P less than .05) in the 23 BG and 60 BG fetuses, with a concurrent increase (P less than .05) in beta-hydroxybutyrate (BOHB) oxidation. Neural lipogenesis measured from acetate and BOHB substrates was nominal in the d 105 pig fetus. Fetal hepatic acetate and BOHB utilization for lipogenesis were increased (P less than .05) by maternal ketosis. Reproductive performance characteristics (litter size, number stillborn and birth weight) were not improved by maternal ketosis. The substantial improvement in lactation weight gain by litters from 23 BG and 60 BG dams (20%, P less than .05) may suggest a carryover effect of gestation dietary treatment on lactation performance.
通过用1,3 - 丁二醇等热量替代葡萄糖，使初产母猪产生全身性酮症，从妊娠第23天（23 BG）或第60天（60 BG）开始提供总日粮能量的20%。酮症降低了（P < 0.05）母体血浆葡萄糖、尿素氮和胰岛素浓度。母体生酮热量替代降低了（P < 0.05）胎儿胴体干物质和胴体糖原含量，而胎儿肝脏糖原和脂质含量不受母体处理的影响。23 BG和60 BG胎儿的神经乙酸氧化降低了（P < 0.05），同时β - 羟基丁酸（BOHB）氧化增加了（P < 0.05）。在第105天的猪胎儿中，由乙酸和BOHB底物测得的神经脂肪生成量极少。母体酮症增加了（P < 0.05）胎儿肝脏对乙酸和BOHB用于脂肪生成的利用率。母体酮症并未改善繁殖性能特征（产仔数、死产数和出生体重）。来自23 BG和60 BG母猪的仔猪在泌乳期体重增加显著改善（20%，P < 0.05），这可能表明妊娠日粮处理对泌乳性能有延续效应。
