Norström A, Bryman I, Wiqvist N, Sahni S, Lindblom B
J Clin Endocrinol Metab. 1984 Sep;59(3):379-82. doi: 10.1210/jcem-59-3-379.
The influence of purified porcine relaxin on contractility of human cervical smooth muscle was investigated in vitro. Strips of cervical tissue were obtained by needle biopsy from pregnant and nonpregnant women and were mounted in a superfused organ chamber for isometric measurement of contractile activity. Relaxin (0.005-25 micrograms/ml) inhibited the spontaneous contractions in cervical strips from 18% of nonpregnant, 68% of early pregnant, and in 100% of term pregnant women. These results indicate that relaxin has an inhibitory action on cervical smooth muscle and that this effect is more constantly detected as pregnancy proceeds.
在体外研究了纯化的猪松弛素对人宫颈平滑肌收缩性的影响。通过针吸活检从孕妇和非孕妇获取宫颈组织条，并将其安装在灌注器官浴槽中以等长测量收缩活性。松弛素（0.005 - 25微克/毫升）抑制了非孕妇宫颈条中18%、早期孕妇宫颈条中68%以及足月孕妇宫颈条中100%的自发收缩。这些结果表明，松弛素对宫颈平滑肌有抑制作用，并且随着妊娠进展这种作用更常被检测到。
