Szefler S J, Rogers R J, Strunk R C
J Allergy Clin Immunol. 1984 Aug;74(2):201-4. doi: 10.1016/0091-6749(84)90287-2.
The case history of a 17-year-old girl with sudden onset of theophylline toxicity and a serum theophylline concentration of 63 micrograms/ml is presented. A change in theophylline elimination was not sufficient to explain this observation. Subsequently, the patient admitted to recent self-medication with several over-the-counter medications and illicit drugs. Although the etiology of theophylline toxicity in this patient could not be defined, several theories are proposed. Included is a discussion of possible interactions of illicit drugs with asthma medications and a summary of personality characteristics associated with a high potential for drug abuse.
本文介绍了一名17岁女孩的病例，她突然出现茶碱中毒，血清茶碱浓度为63微克/毫升。茶碱消除的变化不足以解释这一现象。随后，患者承认最近自行服用了几种非处方药和违禁药物。虽然该患者茶碱中毒的病因尚无法确定，但提出了几种理论。其中包括对违禁药物与哮喘药物可能相互作用的讨论，以及与药物滥用高风险相关的人格特征总结。
