Sturrock R F, Otieno F M, Tarara R, Kimani R, Harrison R, Else J G
J Helminthol. 1984 Jun;58(2):79-92. doi: 10.1017/s0022149x00028546.
Groups of five 3-kg Kenyan monkeys, Cercopithecus aethiops, were exposed individually to 150,600 or 1500 Schistosoma mansoni cercariae per monkey. Three monkeys died soon after the infections became patent and the survivors were autopsied 4 months after exposure. Mortality and most haematological, parasitological and pathological sequelae of infection were dose-related, but not the white cell response or changes in the levels of serum proteins or fibrinogen. No gross liver fibrosis was seen. Comparison of this study with earlier ones on related cercopithecine monkeys suggests that the vervet closely resembles the baboon in its response to S. mansoni infections. Difficulties in managing and maintaining vervets can be overcome by using colony-bred or properly adapted feral animals. Thus, the vervet provides a cheaper, more readily available primate model for experimental S. mansoni studies. A prolonged infection, sufficiently heavy to permit reliable parasitological monitoring without undue mortality, should be provided by 150 S. mansoni cercariae per kg body-weight, using the Kenyan strains of vervet and parasite.
将五只体重3千克的肯尼亚猕猴（非洲绿猴）分为一组，每只猴子分别感染150、600或1500条曼氏血吸虫尾蚴。三只猴子在感染出现明显症状后不久死亡，幸存者在接触后4个月进行解剖。感染的死亡率以及大多数血液学、寄生虫学和病理学后遗症与剂量相关，但白细胞反应或血清蛋白及纤维蛋白原水平的变化并非如此。未观察到明显的肝纤维化。将本研究与早期对相关猕猴属猴子的研究进行比较表明，绿猴对曼氏血吸虫感染的反应与狒狒非常相似。通过使用群体饲养或适当适应的野生动物，可以克服管理和饲养绿猴的困难。因此，绿猴为曼氏血吸虫实验研究提供了一种更便宜、更容易获得的灵长类动物模型。使用肯尼亚绿猴和寄生虫菌株时，每千克体重150条曼氏血吸虫尾蚴应能提供足够严重的长期感染，以便在不过度死亡的情况下进行可靠的寄生虫学监测。
