Delcour C, Garcez J L, Schils J, Vandenbosch G, Dereume J P, Struyven J
J Mal Vasc. 1984;9(2):129-32.
Peripheral artery occlusion produced by thrombosis or embolus can be cured by intra-arterial low dose thrombolysis without severe hemorrhagic complications. 18 patients suffering of acute ischemia of lower limbs were treated by intra-arterial streptokinase infusion. Diagnostic angiography is performed by antegrade femoral puncture using a 5F straight catheter. The tip of the catheter is placed within the thrombus. After a bolus of 10 000 U, streptokinase is infused at the rate of 2,000 U/min. Fibrinolysis is usually achieved within 70 min with a total dose of 150,000 U. Arterial recanalization occurred in 14 patients, in 6 cases underlying stenosis was successfully treated by percutaneous transluminal angioplasty. No severe complications were encountered.
由血栓形成或栓子导致的外周动脉闭塞可以通过动脉内低剂量溶栓治愈，且不会出现严重的出血并发症。18例下肢急性缺血患者接受了动脉内链激酶输注治疗。诊断性血管造影通过使用5F直导管经股动脉顺行穿刺进行。将导管尖端置于血栓内。推注10000U后，以2000U/分钟的速率输注链激酶。通常在70分钟内实现纤维蛋白溶解，总剂量为150000U。14例患者实现动脉再通，6例患者潜在的狭窄通过经皮腔内血管成形术成功治疗。未遇到严重并发症。
