Pompeiano O, Xerri C, Gianni S, Manzoni D
J Neurophysiol. 1984 Jul;52(1):18-38. doi: 10.1152/jn.1984.52.1.18.
The activity of 168 Deiters' neurons projecting to lumbosacral segments of the spinal cord has been recorded in precollicular decerebrate cats after ipsilateral acute (aVN) or chronic vestibular neurectomy (cVN), and their response characteristics to sinusoidal stimulation of contralateral labyrinth receptors at the standard parameters (roll tilt at 0.026 Hz, 10 degrees peak displacement) have been related to cell size inferred from the conduction velocity of the corresponding axons. These findings were compared with those elicited in decerebrate cats with both vestibular nerves intact. In all experimental conditions, the higher the coefficient of variation (CV) of the vestibulospinal neurons, reflecting a more irregular unit discharge, the lower was the mean discharge rate at rest. However, the proportion of regularly discharging units (with the lowest CV) decreased after aVN but increased after cVN. The relation found in control experiments, i.e., the faster the conduction velocity of vestibulospinal axon the lower was the unit discharge at rest, was lost after aVN due to a decrease in resting discharge rate of the slow neurons. The mean discharge rate of these units, however, recovered after cVN, so that the negative correlation between resting discharge rate and axonal conduction velocity was reestablished. After aVN, the decrease in resting discharge rate of the slow vestibulospinal neurons was not associated with significant changes in gain (impulses per second per degree) of the unit responses to standard parameters of tilt, so that the sensitivity of these units (percentage change of the mean discharge rate per degree) increased; on the other hand, the resting discharge rate of the fast neurons, which remained almost unchanged after aVN, was associated with a significant increase in gain, thus leading to an average increase in response sensitivity of these units.(ABSTRACT TRUNCATED AT 400 WORDS)
在同侧急性（aVN）或慢性前庭神经切除术（cVN）后，对去大脑皮层猫中投射至脊髓腰骶段的168个Deiters神经元的活动进行了记录，并将它们对以标准参数（0.026Hz滚动倾斜，峰值位移10度）对侧迷路感受器进行正弦刺激的反应特性，与根据相应轴突传导速度推断出的细胞大小相关联。将这些结果与双侧前庭神经完整的去大脑皮层猫所获得的结果进行比较。在所有实验条件下，反映单位放电更不规则的前庭脊髓神经元变异系数（CV）越高，静息时的平均放电率越低。然而，规则放电单位（CV最低）的比例在aVN后降低，但在cVN后增加。在对照实验中发现的关系，即前庭脊髓轴突传导速度越快，静息时单位放电越低，在aVN后由于慢神经元静息放电率降低而消失。然而，这些单位的平均放电率在cVN后恢复，因此静息放电率与轴突传导速度之间的负相关得以重建。aVN后，慢前庭脊髓神经元静息放电率的降低与单位对标准倾斜参数反应的增益（每秒每度冲动数）的显著变化无关，因此这些单位的敏感性（平均放电率每度的百分比变化）增加；另一方面，快速神经元的静息放电率在aVN后几乎保持不变，与增益的显著增加相关，从而导致这些单位的反应敏感性平均增加。（摘要截断于400字）
